However, CRS had no effects on the frequency of periodic acid-Schiff (PAS)+ secretory goblet cells, lysozyme (Lyz)+ Paneth cells and chromogranin A (ChgA)+ enteroendocrine cells per crypt-villus unit of the small intestine (Supplementary Fig. S1h‒m). The gene discussed is CHGA; the disease is congenital rubella syndrome.