To increase the translational significance of our study, the effects of three small-molecule inhibitors, VX765, which specifically inhibits Caspase-1,35 MCC950, which specifically inhibits the NLRP3 inflammasome,36 and SRI-37330, which specifically inhibits TXNIP,37 on DOXIC in a PDX breast cancer model were examined. The gene discussed is CASP1; the disease is breast cancer.