Their role in tobacco-related CHD remains unclear.<h4>Objective</h4>To investigate the effect of APOL1 risk variants on the association between tobacco smoking and prevalent CHD in African American adults.<h4>Methods</h4>We conducted a cross-sectional study involving 519 African American adults recruited through the University of California San Francisco Lipid Clinic. The gene discussed is APOL1; the disease is coronary artery disorder.