Also in agreement with DAT;NuTRAP data, the highest change in gene expression for both males and females was in genes connected to pathways of neurodegeneration (Fig. 6D), corroborating what is known about aging being a factor in neurodegenerative diseases (Baker and Petersen, 2018), but in a second type of midbrain neuron. The gene discussed is SLC6A3; the disease is neurodegenerative disease.