ACE and neurodegenerative disease: In the brain RAS, angiotensinogen is mainly expressed as astrocytes in various regions of the brain, then converted into several peptides to play physiological roles.28Among them, ACE 1 converts angiotensin I to II (AT-I to -II), which can increase the activation of cell apoptosis, neuroinflammation, and oxidative stress.29Also, ACE contributes to the pathogenesis of neurodegenerative diseases.32, 33The main effect of ACEIs could selectively inhibit ACE 1 and reduce the production of AT-II.