The risk of ALST may be down-regulated by the treatment with angiotensin-converting enzyme inhibitors (ACEIs), as illustrated by a population-based case-control study.8Additionally, various subsequent observational studies and meta-analyses found that AHMs could lower the incidence of ALS.9, 10, 11However, there were also trials that had not reached reliable positive conclusions.12The inconsistencies in the above findings were largely attributed to the influence of reverse causality, sample size limitations, and confounding factors. Here, ACE is linked to amyotrophic lateral sclerosis.