Subsequent WES revealed pathogenic variants in 8 (73%), including 4 in the X-linked genes (DDX3X[2 cases],WDR45, andPDHA1), and 4 in the autosomal genes (KCNB1,CTNNB1,YY1, andANKRD11), all associated with dominant neurodevelopmental disorders.69 The gene discussed is WDR45; the disease is neurodevelopmental disorder.