In a study57involving 21 patients from 17 Brazilian families with complex, heterogeneous hereditary spastic paraplegia (HSP) phenotypes, WES was used after previous negative results for SPG11/KIAA1840andSPG7mutations, and it provided a definitive genetic diagnosis in 13 patients from 12 unrelated families, a diagnostic yield of 62%. This evidence concerns the gene SPG11 and hereditary spastic paraplegia.