Specifically, developing comprehensive and comparative genome‐wide binding maps for Bcl‐3, IκBNS, and IκBζ in the same cell type, using Cut&Run or Cut&Tag technologies would be an invaluable resource to uncover the function of atypical IκBs, especially in lymphocytes and in the setting of autoimmunity and autoinflammatory diseases. Here, NFKBIZ is linked to Autoimmunity.