In this phase IIA clinical study, upregulated expression of cancer-associated genes, including those linked to tumorigenesis and metastasis, such as VEGF-A, NR4A3, MKi67, and EpCAM were detected as early as Day 1 in the iCCA patients (Groups 1, 2, and 3). This evidence concerns the gene NR4A3 and infantile convulsions and choreoathetosis.