To further support the importance of intestinal rather than hepatic Zbp1 in mediating the effect on ethanol-induced liver disease, we generated mice with specific deletions of Zbp1 in Kupffer cells (Zbp1ΔKC) (Supplemental Figure 6, A and B) and hepatocytes (Zbp1ΔHep) (Supplemental Figure 6, H and I). The gene discussed is ZBP1; the disease is liver disorder.