First, we tested whether bound (i.e., esterified) oxylipins involved in inflammation and inflammation resolution are altered in transgenic AD rats expressing mutations in the human Swedish amyloid precursor protein (APPswe) and Δ exon 9 mutant presenilin-1 (PS1ΔE9), that were exposed to filtered air (FA) or chronic TRAP, a significant risk factor for AD pathogenesis. The gene discussed is PSEN1; the disease is Alzheimer disease.