Of the ~17 significantly altered oxylipins in TgF344-AD rats exposed to FA or TRAP, 11 (65%) have proresolving effects in vivo, 2 (11-HETE, 20-HETE) have proinflammatory effects, and 4 are sEH inactivation products of fatty acid epoxides (11,12-DiHETrE, 14,15-DiHETrE, 16,17-DiHDPA, and 19,20-DiHDPA). The gene discussed is EPHX2; the disease is Alzheimer disease.