Chronic systemic inflammation, characterized by elevated levels of pro-inflammatory cytokines such as TNF-α and IL- 6, contributes to endothelial dysfunction, increased arterial stiffness, and dysregulation of the renin–angiotensin–aldosterone system, all of which are key factors in the development of hypertension [90, 91, 93]. The gene discussed is TNF; the disease is hypertensive disorder.