GLP1R and obesity due to melanocortin 4 receptor deficiency: In particular, the prevalence of psoriasis is increased in individuals with obesity, and obesity may aggravate existing psoriasis, while diet, bariatric surgery, and glucagon-like peptide- 1 receptor agonists, a class of drugs for the treatment of type 2 diabetes and obesity, appear to contribute to improving psoriasis lesions [125].