In this study, ANXA2P2 was also found to be positively correlated with the abundance of Holdemania, and ANXA2P2 was significantly correlated with CD8 + T cells depletion in gliomas, which further indicated the association between Holdemania and CD8 + T cells [61, 62].However, the specific mechanisms require further exploration. The gene discussed is ANXA2P2; the disease is central nervous system cancer.