Targeted next-generation sequencing of isolated tumour DNA revealed wildtype sequences for BRAF, KIT, NRAS and GNA11 while showing a gain-of-function mutation of GNAQ (p.Q209L) with a variable allele frequency (VAF) of 41.4% as well as a variant of SF3B1 (p.R625H) with a VAF of 39%. Here, GNA11 is linked to neoplasm.