The causal role of inherited or acquired thrombophilia in MINOCA pathogenesis remains highly controversial, but some data suggest an increased frequency of Factor V Leiden and the prothrombin variant G20210A in these patients,123 with the pooled prevalence of thrombophilia being 14% across eight studies.120 The spectrum of MINOCA aetiologies and relevant differential diagnoses (e.g. myocarditis, Takotsubo cardiomyopathy) are broad, making functional coronary angiography and/or multimodality imaging, including cardiac magnetic resonance (CMR), a necessity.124. Here, F5 is linked to Rare hereditary thrombophilia.