Furthermore, the Janus structure achieves functional synergy between GOX and CAT through spatial partitioning: the hydrophobic side targets GOx delivery to induce tumor disulfidptosis, while the hydrophilic side clears H2O2 and alleviates oxidative damage, avoiding the side effects caused by H2O2 accumulation in traditional single-function materials, such as GOx-only films. The gene discussed is HAO1; the disease is neoplasm.