Figure 7j,m shows the presence of SOX2 and HIF-1α in dedifferentiated CSC-like cells (the bright yellow nuclei—SOX2—with red/orange cytoplasm for HIF-1α) and the cancer cells (the green cells in the background) in one frame, which is a sign of reviving the neoplasm or heterogeneity of the TME (see Supplementary Materials for the additional photos, Figure S13). Here, SOX2 is linked to neoplasm.