According to their transcriptomic profile, GBM tumors were classified into three major subtypes: classical (characterized by amplification/mutation in EGFR), proneural (characterized by alterations in PDGFRA or by homozygous deletion of CDKN2A), or mesenchymal (characterized by deletions in NF1 or PTEN) subtypes. The gene discussed is EGFR; the disease is glioblastoma.