SLC5A2 and aortic stenosis: This overexpression was also demonstrated in the study by Scisciola et al. In this case, overexpression of the SGLT2 gene and protein was marked in patients with low flow, low gradient aortic stenosis (LF-LG AS), and this overexpression appeared to be related to important changes in cardiac metabolism: in particular, there was less utilization of fatty acids and their oxidation to produce energy, with greater utilization of glucose as an energy substrate and subsequent accumulation of lipids in the myocardium.