Since pressure overload in severe AS leads to a metabolic imbalance in the heart with predominance of glucose metabolism over lipid metabolism and subsequent accumulation of lipids in the myocardiocytes, several studies have investigated if this behaviour can be reversed in consideration of the presence of increased expression of SGLT2 especially in patients with low flow, low gradient AS, hypothesizing that an early initiation of SGLT2i in these patients may improve the final outcome and remodelling [12]. Here, SLC5A2 is linked to aortic stenosis.