Additionally, some data show the upregulation of anti-apoptotic Bcl-2 RNA expression and the downregulation of pro-apoptotic FADD and BAX expression in males, consistent with a protective effect, whereas affected female mice have a significantly shorter lifespan, and female patients with CLN6 disease often show increased clinical severity. Here, BAX is linked to ceroid lipofuscinosis, neuronal, 6A.