It was found that MMP-2, MMP-9, TIMP-1, and TIMP-2 gene expression in post-operational material was significantly lower in the CRSsNP group compared to the control group, p < 0.0001, and CRSwNP group, accordingly MMP-2 8.321 ± 2.591 vs. 1.692 ± 3.230 ΔΔCT over the control group, p < 0.0001; MMP-9 9.928 ± 2.017 vs. 1.344 ± 2.509 ΔΔCT over the control group, p < 0.0001; TIMP-1 10.50 ± 3.357 vs. 2.392 ± 3.775 ΔΔCT over the control group, p < 0.0001; TIMP-2 5.710 ± 2.980 vs. 1.152 ± 2.327 ΔΔCT over the control group, p < 0.0001. Here, MMP2 is linked to chronic rhinosinusitis without nasal polyps.