Although inflammatory endotyping provides a more accurate reflection of the underlying immunopathology—particularly in distinguishing type 2 eosinophilic CRS from other variants—this classification requires consistent histopathological data, including eosinophil counts, as well as immunoassays for key cytokines such as IL-4, IL-5, and IL-13. The gene discussed is IL5; the disease is congenital rubella syndrome.