Using a mouse model ablated for the Glrx2 gene (Glrx2−/−), we were able to show that the induction of KGDH S-glutathionylation protects male C57Bl6N mice from the manifestation of non-alcoholic fatty liver disease (NAFLD) caused by dietary fat overload (Figure 3) [43]. The gene discussed is GLRX2; the disease is metabolic dysfunction-associated steatotic liver disease.