IGHE and allergic disease: Specifically, epithelial barrier dysfunction and Th2-mediated inflammation may be alleviated by our unified interventions, such as instructions of daily moisturizing routines and environmental trigger avoidance, which collectively disrupt the progress of “atopic march.” This aligns with recent evidence showing that early skin barrier enhancement in infants [75-77] or allergen reduction [78-80] can lower IgE sensitization risks and reduce comorbid allergies, supporting the clinical value of holistic approaches over siloed disease management.