Hypertension primarily affects the left atrium through hemodynamics and neurohormonal mechanisms, resulting in increased left atrial pressure, elevated release of atrial natriuretic peptide and angiotensin, leading to structural remodeling characterized by atrial fibrosis, electrical remodeling, Ca2+ handling remodeling, and pro‐inflammatory remodeling, ultimately culminating in impaired left atrial contraction function and AF [25, 26]. The gene discussed is NPPA; the disease is Hypertension.