Furthermore, recent data highlight the relevance of genetic variants in the genes encoding NaPi-IIa (SLC34A1) and NaPi-IIc (SC34A3) in pediatric patients with Infantile idiopathic hypercalcemia or Hereditary Hypophosphatemic Rickets with Hypercalcuria (HHRH), and in adults with kidney stones as well as in patients with chronic kidney disease (CKD). Here, SLC34A1 is linked to nephrolithiasis.