ZDHHC4 and diabetes mellitus: Cardiac FoxO1 is known to be stimulated in diabetes,52,53 and its inhibition, through cardiac-specific FoxO1 deficient mice (FoxO1Cardiac−/−), was able to correct overall cardiac substrate metabolism.14 Thus, by identifying the axis between FoxO1-zDHHC4-CD36, we now provide a new mechanism to explain how FoxO1 dysregulates metabolism and contractile function in the diabetic heart.