INS and type 2 diabetes mellitus: Inducing T2D in the rat using a combination of high-fat diet and low-dose streptozotocin resulted in a mild model of T2D characterized by a 36% increase in fasting blood glucose, a 2-fold increase in nonesterified FA concentrations, and a 44% increase in fasting insulin concentrations, accompanied by increased adiposity with no significant differences in heart weight (Table S3).