CD36 and diabetes mellitus: Preferential sarcolemmal relocalization of CD36 from intracellular vesicles to the plasma membrane has been identified as one of the first changes within muscle in response to a diabetogenic diet in rodents7,47 and humans,48 which, in time, is accompanied by an increase in CD36 total protein content as diabetes progresses.49 As such, understanding what drives this initial relocalization of CD36 to the membrane has been an active area of interest in many pathologies.