The main regulatory enzymes mediating CD36 S-acylation are zDHHC4 and zDHHC5 (zinc finger DHHC-type palmitoyltransferase 5),10 and the main de-S-acylating enzyme is APT1 (Acyl protein thioesterase 1)9; therefore, the expression of these proteins was investigated in diabetes (Figure 3C). Here, ZDHHC4 is linked to diabetes mellitus.