When compared to non-CF neutrophils, CF neutrophils shed less L-selectin and are less responsive to IL-8 due to the downregulation of CXCR2, increased mucus in the bronchial epithelium, and the presence of Pa-produced alginate (Hayes et al., 2011; Aslanhan et al., 2021; Laucirica et al., 2022; Hu et al., 2024). The gene discussed is CXCR2; the disease is cystic fibrosis.