Lymphoid cells express the CFTR protein and in CF, they are ineffective in clearing Pa at least partially due to being Th17 and Th2 cells rather than Th1, which leads to impaired antigen presentation, increased levels of immunoglobulin (Ig) E, and excessive neutrophil infiltration (Harwood et al., 2021). This evidence concerns the gene CFTR and cystic fibrosis.