VTN and infection: Given that PLT exhibits hallmark structural and functional characteristics that are associated with their participation in host defense against infection, such as rapid response to agonists associated with vascular trauma or infection and accumulation at sites of endovascular damage or microbial colonization, and it was found that activation of PLT by agonists generated in situations aforementioned could enhance PLT interactions with complement proteins, humoral immune components, leukocytes, and endothelial cells (Yeaman, 1997).