As reported, the pathophysiology of organ damage that emerged in the HTNV infection also motivates the increase in inflammatory biomarkers, including the C-reactive protein (CRP), coupled with the sensitivity of this parameter for viral infection and inflammation, it was used to evaluate disease severity and predict outcomes of COVID-19 patients and play a vital role in the treatment of HFRS (Che et al., 2022; Shin et al., 2018; Liu et al., 2020). The gene discussed is CRP; the disease is viral infectious disease.