PRPF8 and retinitis pigmentosa: For example, the use of CRISPR/Cas9 technology to introduce heterozygous point mutations in the PRPF8 gene of normal induced pluripotent stem cell (iPSC) lines and establish PRPF8 gene mutant cell lines (CSUASOi012-A-2) has provided valuable cellular resources for studying the pathogenesis of retinitis pigmentosa (Chen et al., 2025).