To further explore the relationship between TIMP3 and the tumor immune microenvironment, the analysis was performed by an algorithm of immune cell infiltration, and we found that the expression of TIMP3 correlated significantly with the immune infiltration of fibroblasts, tumor-associated fibroblasts, and M2-type macrophages, and the higher the expression of TIMP3, the more pronounced the CAFs and M2 infiltration (Figures 5C–E, G, J). Here, TIMP3 is linked to neoplasm.