CD47 and ovarian cancer: Lin et al. (2022) found that Periostin enhances the M2 through integrin-mediated NF-κB and TGF-β2 signaling pathways. Macrophages and cancer-associated fibroblasts to promote ovarian cancer metastasis. High CD47 expression was found to be closely associated with immune infiltration of ovarian cancer cells, thereby affecting the tumor microenvironment and possibly inducing ovarian cancer heterogeneity (Yu et al., 2021).