In our study, single-cell transcriptome data of primary and metastatic ovarian cancers were selected for analysis in the GEO database, and differential genes (THY1, TIMP3, IFI27, CCDC80, DUSP1) of CAF in primary and metastatic ovarian cancers were screened for in-depth analysis, which clarified that the communication between fibroblasts and M2-type macrophages by CXCL12-CXCR4 axis mediated by CAF, which promotes macrophage polarization towards M2. This evidence concerns the gene IFI27 and ovarian cancer.