Further analysis in different tumor datasets showed that the proportion of tumor cells that were unresponsive to immunotherapeutic drugs was higher in both TIMP3 high expression groups than in the TIPM3 low expression group, and this result demonstrated that high expression of TIMP3 could enhance the immunosuppressive ability of tumor cells, thus enhancing their immunotherapeutic resistance (Figures 6C–J). This evidence concerns the gene TIMP3 and neoplasm.