To explore the key genes in the model genes, we studied five genes in depth and found that in metastatic ovarian cancer, fibroblasts induced macrophage polarization to M2-type macrophages through the TIMP3-regulated CXCL signaling pathway, which in turn affected the prognosis of ovarian cancer patients and the drug resistance of ovarian cancer cells. Here, TIMP3 is linked to ovarian carcinoma.