ARHGEF4 and preeclampsia: LEP and ARHGEF4, involved in metabolic and hypoxia/angiogenesis pathways, are shown to be upregulated (in accordance with our result) in placentas from severe preeclampsia (sPE) patients across ancestries, suggesting its contribution to the pathophysiology of preeclampsia (Aisagbonhi et al., 2023).