The genes lacking disease-association evidence but with similar characteristics with the above two groups were considered as ‘potential minor-effect biomarkers’: are SRRM2 - AS1 (shared), ATP8A1 (PAH - specific), RXFP1 and HJURP (HAPC - specific), HIST1H1T (PE - specific). The gene discussed is H1-6; the disease is pulmonary arterial hypertension.