Due to the molecular homogeneity of CIMP-high, BRAF-mutant CRCs and serrated colorectal cancer (JE et al., 2015), many studies have used CIMP status and BRAF mutation as molecular markers to identify serrated colorectal cancer (Mesteri et al., 2014; Kriegl et al., 2011; Bleijenberg et al., 2022). This evidence concerns the gene BRAF and colorectal cancer.