A statistically significant increase in age, RDW, GPR, APRI and FIB-4, and a significant decrease in mean Hb, PLT, Alb, and FIB-5 were observed in patients with moderate–severe fibrosis (S2–S4) when compared with absent-mild liver fibrosis (S0–S1). The gene discussed is GSTM1; the disease is fibrosis.