Recently, a growing number of studies indicate that a new model, fibrosis-5 index (FIB-5), which combines Alb, platelet count (PLT), alkaline phosphatase (ALP), AST and alanine aminotransferase (ALT) values, is superior to FIB-4 for diagnosing significant hepatic fibrosis in patients with chronic HBV and HCV infections (16, 17). This evidence concerns the gene ALB and Hepatic fibrosis.