Non-invasive liver fibrosis models composed of simple parameters have been developed to predict liver fibrosis in patients with viral hepatitis, such as fibrosis index based on fibrosis-4 index (FIB-4), aspartate transaminase (AST)-to-platelet ratio index (APRI), gamma-glutamyl transpeptidase-to-platelet ratio (GPR) (9–14). This evidence concerns the gene GGTLC1 and Hepatic fibrosis.