AKT1 and intrahepatic cholangiocarcinoma: Table 3 and Supplementary Tables 1–3 present a comparative analysis of the clinical performance of Akt, mTOR, and Pax-2 biomarkers using IHC and ICC, evaluating sensitivity, specificity, Youden’s index, and area under the curve (AUC) at ideal thresholds to determine their diagnostic efficacy.