Of the 184 mediators examined, Galectin-3 (GAL3) and Interleukin 1 receptor, type I (IL-1RT1) (red in Figure 1D), were significantly elevated in the apical wash of the COPD subjects, while SPON1, TNSF13B, CD93, GP6, Notch3, SHSP-1, MPO, SCGB3A2, and PCSK9 (blue in Figure 1D) were significantly lower. Here, NOTCH3 is linked to chronic obstructive pulmonary disease.