Although not significant, many SASP factors trended toward an increase in IGFBP2, IGFBP7, PAI-1, uPA, IL-6, and MMP-2 in COPD ALI cultures (orange in Figure 1D), a full list of proteins examined and their log fold change and adjust p-values can be seen in Supplementary Table 1. This evidence concerns the gene SERPINE1 and chronic obstructive pulmonary disease.