In Figure 8B, ELISA analysis also showed that CSF Aβ1-42 production was elevated in AD rat (P < 0.001), NTN-1 treatment reversed the increase of Aβ1-42 (P < 0.05), which might suggest NTN-1 regulate APP processing and inhibits Aβ amplification. The gene discussed is NTN1; the disease is Alzheimer disease.