Multiple inflammatory pathways are involved in the pathological process of Alzheimer's disease, while our hypothesis-driven approach centered on NLRP3/NF-κB due to their established AD relevance, other potential inflammatory pathways, such as the JAK-STAT pathway, may be implicated in AD progression need to be further explored in the future. Here, NFKB1 is linked to early-onset autosomal dominant Alzheimer disease.