NTN-1 strongly exerts an anti-inflammatory properties by suppressing NF-κB pathway activation in endothelial cells and subarachnoid hemorrhage rats, and it also plays a critical role in preventing NF-κB and caspase-3/7 activation and ROS damage by microinjection in AD rats and SH-SY5Y cells (Lin et al., 2018; Xie et al., 2018; Zamani et al., 2020, 2019). Here, NTN1 is linked to Alzheimer disease.