Based on current evidence, we hypothesize that NTN-1 lowered the Aβ1-42 induced NLRP3 inflammasome-mediated inflammatory response and microglia activation, through modulating the PI3K/eNOS/NF-kB signaling pathway in the hippocampal and cortical tissues of AD rats, which might bind to its receptor Unc5b. The gene discussed is NTN1; the disease is Alzheimer disease.