A study on the relationship between VNS and cerebrospinal fluid circulation reported that VNS after stroke-induced VCI can enhance cerebrospinal fluid circulation (Cheng et al., 2020), which is beneficial for the metabolism and excretion of toxic metabolites in the brain substance during the progression of ischemic stroke, such as amyloid-beta and Nogo-A. Here, RTN4 is linked to stroke disorder.