Animal experiments with laser acupuncture at DU20 (Baihui) have shown a significant increase in neuronal density in the CA1 and CA3 regions, increased activity of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), decreased IL-6 and β-amyloid density ratio, exerting antioxidant and anti-inflammatory effects, thereby alleviating cognitive impairment in focal ischemic rats (Jittiwat, 2019). This evidence concerns the gene PPIB and Cognitive impairment.