When acupuncture was applied to rats with ketamine-induced cognitive impairment (Miao et al., 2023), it was found that the rats’ neurological and behavioral symptoms improved, and the neurodegeneration of the locus coeruleus (LC) was alleviated, possibly due to EA regulating the Calmodulin-Dependent Protein Kinase II (CAMKII)/cAMP Response Element-Binding Protein (CREB) pathway, thus mitigating the adverse effects mentioned above. This evidence concerns the gene CREB1 and Cognitive impairment.