Our study used the well-characterized TgF344-AD rat model of AD (Cohen et al., 2013), which expresses two human genes implicated in familial early-onset AD driven by the mouse prion promoter: the “Swedish” mutant amyloid precursor protein (APPsw) and the presenilin-1 exon 9 deletion (PS1ΔE9). The gene discussed is PSEN1; the disease is Alzheimer disease.