Also, sifting for orthopaedic conditions, 20 factors were related to ‘Musculoskeletal system disease’ [DOID:17], mainly at inflammatory (‘Inflammatory’ and ‘Immune response’: KIT, CSF1R, CD40, IL2RA, IL23A, TGFB1 and FAS) and matrix (‘positive regulation of collagen biosynthetic process’, GO:0032967: TGFB1, BMP4 and PDGFRB) levels. This evidence concerns the gene CD40 and musculoskeletal system disorder.