Interestingly, PPARα is closely implicated in the pathophysiology of depression (Scheggi et al., 2016; Chen et al., 2019a; Wang et al., 2021b; Gao S. et al., 2022), and in 2018, Song et al. explored the role of central PPARα in depression comprehensively (Song et al., 2018). Here, PPARA is linked to depressive disorder.