Interestingly, PPARα is closely implicated in the pathophysiology of depression (Scheggi et al., 2016; Chen et al., 2019a; Wang et al., 2021b; Gao S. et al., 2022), and in 2018, Song et al. explored the role of central PPARα in depression comprehensively (Song et al., 2018). The gene discussed is PPARA; the disease is major depressive disorder.