Downregulation of METTL14 expression in ESCC significantly enhances the resistance of ESCC to radiation therapy by hindering the maturation process of miR-99a-5p and deregulating the inhibitory effect of miR-99a-5p on TRIB2 expression (Liu Z. et al., 2021). The gene discussed is TRIB2; the disease is esophageal squamous cell carcinoma.