Other methyltransferases can also induce drug resistance, such as METTL14, which can regulate CircUGGT2 through m6A-dependent modifications, promoting cell proliferation, metastasis, and the development of DDP resistance in GC by adsorbing miR-186-3p and upregulating mitogen-activated protein kinase kinase 9 (MAP3K9) (Chen X. Y. et al., 2024). Here, MAP3K9 is linked to gastric cancer.