In addition, downregulation of METTL14 reduced m6A modification of C/EBP homologous protein (CHOP) mRNA and decreased CHOP protein levels, and low CHOP levels reduced the apoptosis-inducing effect of REGO on tumor cells, increasing tumor resistance to REGO (Pan Y. et al., 2024) (Figure 3A). This evidence concerns the gene DDIT3 and neoplasm.