NEK2, a serine/threonine kinase, is essential in the cell cycle, and its dysregulation can lead to chromosomal instability, aneuploidy in cancer cells, activation of oncogenic signaling pathways, selective mRNA splicing, p53 loss, cilia disassembly, and tumor immune evasion (Xia et al., 2024). The gene discussed is TP53; the disease is neoplasm.