Functional enrichment analyses yielded consistent results across various cancers, indicating that SF3B6 expression was closely related to RNA splicing, DNA replication, cell cycle regulation, DNA damage repair, pathways associated with multiple cancer types, immune response pathways, tumor metabolic pathways, and classical tumor-related pathways (e.g., KRAS, PI3K/AKT/mTOR, MYC). This evidence concerns the gene AKT1 and neoplasm.