DNMT1 and transient ischemic attack: However, this contrasts with previous reports suggesting that inhibiting DNMT function exerted neuroprotective effects, where inhibition of DNMT3A in a mouse model of transient cerebral ischemia increased infarct volume and exacerbated neurobehavioral impairments, with an increase in the number of neutrophils and infiltration of peripheral blood and central neutrophils (Lyu et al., 2024).