TNF and metabolic dysfunction-associated steatohepatitis: As NASH evolves, LSECs show a pro-inflammatory phenotype, which is characterized by enhancing the expression of vascular adhesion protein 1, platelet endothelial cell adhesion molecule 1, e-selectin, intercellular adhesion molecule 1, cyclooxygenase 2, IL-6, nicotinamide adenine dinucleotide phosphate-oxidase 2, and TNF-α (Kus et al., 2019).