In terms of mechanism, NAI plays critical roles in various signaling pathways in degenerative diseases through modulating angiogenesis (Kandhare et al., 2014), inhibiting apoptotic proteins such as caspases and Bcl-2 family members, and activating prosurvival pathways like the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway, which promotes cell survival and inhibits apoptosis (Wang et al., 2020). The gene discussed is AKT1; the disease is neurodegenerative disease.