NLRX1 and infection: Following infection with a variety of viruses, including simian virus 5 (SV5), sendai virus (SeV), vesicular stomatitis virus (VSV), H1N1 influenza A virus, and the RNA analog poly (I:C), a significant increase in IFN-β production was observed in Nlrx1-/- mouse embryonic fibroblasts (MEFs) and in mice that was not observed at basal levels.