On the other hand, B7-H3 inhibited the secretion of IFN-γ, IL-2, perforin, and granzyme B, thereby suppressing the activity of CD4+ T cells, CD8+ T cells, γδ T cells, CAR-T cells, Vδ2 T cells, T17 cells, CD3+ T cells, NK cells, macrophages, neutrophils, and DCs (121–124), while B7-H3 regulated the differentiation of tumor-associated macrophages, promotes polarization of type 2 macrophages, and converts the M1 phenotype to the M2 phenotype (125). Here, CD4 is linked to neoplasm.