CD276 and obesity due to melanocortin 4 receptor deficiency: Studies have shown that B7-H3 is abundantly expressed in mouse and human adipose tissue and preferentially expressed in adipocyte progenitor cells (APs), and knockdown of the gene leads to spontaneous obesity in mice, demonstrating a role for B7-H3 in adipocyte progenitor cell differentiation, lipid oxidation, and obesity, in addition to its immunomodulatory function (127).