HMB-002 is an IgG4 type antagonistic monoclonal antibody against VISTA that does not rely on Fc. It was developed under the guidance of AI and targets a conserved specific functional epitope on the C-C ‘ring specific to VISTA. It has shown effective inhibition of tumor growth in humanized mouse cancer models of preclinical colorectal cancer, lung cancer and breast cancer. The gene discussed is VSIR; the disease is lung cancer.