TIM-3 is selectively expressed on IFN-γ-secreting helper T cells (Th1 and Th17), Tregs, mast cells, DCs, NK cells, tumor-infiltrating lymphocytes (TILs), monocytes, as well as on tumor cells such as melanoma, gastric cancer, and B-cell lymphoma (214). The gene discussed is IFNG; the disease is neoplasm.