CASP4 and obesity due to melanocortin 4 receptor deficiency: We here found that that LPS-mediated LncRNA lncRNA29RIK in macrophages can promote the oligomerization of the LPS/caspase-4/11 complexes upon exposure to LPS/dotap, which can cause tissue inflammation and promote sensitivity to obesity through the LPS-mediated release of mature (m) IL-1β and pyroptosis of macrophages.