We here found that that LPS-mediated LncRNA lncRNA29RIK in macrophages can promote the oligomerization of the LPS/caspase-4/11 complexes upon exposure to LPS/dotap, which can cause tissue inflammation and promote sensitivity to obesity through the LPS-mediated release of mature (m) IL-1β and pyroptosis of macrophages. This evidence concerns the gene CASP4 and Obesity.