During sepsis, the bone marrow releases a large amount of immature granulocyte (IGs) through emergency granulopoiesis (37), such as CEACAM8+Neu, S100A8/9hiNeu, IL1R2+Neu, PADI4+Neu, MPO+Neu and cycling MK167+CYP1B1+Neu (38). The gene discussed is S100A8; the disease is Sepsis.