METTL3 and preeclampsia: Reducing METTL3 activity has been shown to significantly reduce m6A methylation levels in placental trophoblasts from individuals with preeclampsia, which in turn affects the expression of heterogeneous ribonucleoprotein complex members C1/C2 (hnRNPC1/C2); in addition, this process involves the maturation of miRNA 497-5p/145-5p (135).