In SLE, IFN-I production originates from dendritic cells, neutrophils, and monocytes/macrophages (21), encompassing thirteen IFN-α subtypes, IFN-β, and rare variants (IFN-ε, IFN-κ, IFN-ω) (34). The gene discussed is IFNA1; the disease is systemic lupus erythematosus.