Dietary interventions further expand this paradigm – aged garlic oligosaccharides reshape gut ecology toward Akkermansia-dominant communities with concomitant TMAO reduction in hyperlipidemic ApoE-/- models, whereas hickory polyphenols attenuate atherosclerosis through hepatic FMO3 transcriptional downregulation in high-choline-fed C57BL/6J mice (167, 168). The gene discussed is APOE; the disease is atherosclerosis.